This is the Linux app named MetaEntropy whose latest release can be downloaded as MetaEntropy_1.1.tar.gz. It can be run online in the free hosting provider OnWorks for workstations.
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MetaEntropy
DESCRIPTION:
Estimates Shannon entropy, per gene and per genomic position, associated with non-synonymous mutation frequencies in viral populations, such as wastewater samples or quasispecies. By categorizing amino acids based on their physicochemical properties, the package determines whether a mutation is functionally disruptive or neutral. Provides normalized values (0-1 scale) to facilitate the direct comparison of different genomic positions or total functional entropy across multiple metagenomes. Designed to analyze mutational data using tabular 'Single Nucleotide Variant' (SNV) frequency tables generated by variant callers (e.g., 'iVar' or 'LoFreq'), operating independently of consensus sequence estimation and multiple sequence alignment.
This is an application that can also be fetched from https://sourceforge.net/projects/metaentropy/. It has been hosted in OnWorks in order to be run online in an easiest way from one of our free Operative Systems.