This is the Windows app named StochDecomp whose latest release can be downloaded as StochDecomp_v28102013.zip. It can be run online in the free hosting provider OnWorks for workstations.
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Stochasticity is an indispensable aspect of biochemical processes at the cellular level. Studies on how the noise enters and propagates in biochemical systems provided us with nontrivial insights into the origins of stochasticity, in total however they constitute a patchwork of different theoretical analyses. Here we present a flexible and generally applicable noise decomposition tool, that allows us to calculate contributions of individual reactions to the total variability of a system’s output. With the package it is therefore possible to quantify how the noise enters and propagates in biochemical systems. We also demonstrate and exemplify using the JAK-STAT signalling pathway that it is possible to infer noise contributions resulting from individual reactions directly from experimental data. This is the first computational tool that allows to decompose noise into contributions resulting from individual reactions.
This is an application that can also be fetched from https://sourceforge.net/projects/stochdecomp/. It has been hosted in OnWorks in order to be run online in an easiest way from one of our free Operative Systems.