This is the Linux app named Power Decoder whose latest release can be downloaded as PowerDecoder-1.0.0.tar.gz. It can be run online in the free hosting provider OnWorks for workstations.
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Power Decoder
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DESCRIPTION
RNA interference (RNAi) screening using pooled, short hairpin (sh)RNA is a powerful, high-throughput tool for determining the biological relevance of genes for a phenotype. Assessing an shRNA pooled screen’s performance is difficult in practice; one can estimate the performance only by using reproducibility as a proxy for power or by employing a large number of validated positive and negative controls. Here, we develop an open-source software tool, the Power Decoder simulator, for generating shRNA pooled screening experiments in silico that can be used to estimate a screen’s statistical power. Using the negative binomial distribution, it models both the relative abundance of multiple shRNAs within a single screening replicate and the biological noise between replicates for each individual shRNA. The Power Decoder simulator is written in R and Python.
User interface
Console/Terminal
Categories
This is an application that can also be fetched from https://sourceforge.net/projects/powerdecoder/. It has been hosted in OnWorks in order to be run online in an easiest way from one of our free Operative Systems.
